DMT and 5-MeO-DMT are two powerful psychedelic substances that are both found in nature. DMT (dimethyltryptamine) is found in many species of plants, including Psychotria viridis (found in most ayahuasca brews), and is considered one of the ‘classic’ psychedelics (alongside LSD, psilocybin, and mescaline). 5-MeO-DMT (5-methoxy-dimethyltryptamine) is a close chemical relative of DMT, and is found in many plants but also in the venom of the Bufo alvarius toad.

Although their names are similar, DMT and 5-MeO-DMT have different effects. When both are smoked, DMT produces a short-lasting psychedelic experience of a few minutes, with very few physical effects; while the 5-MeO-DMT experience lasts up to half an hour and can be intensely physical.

The DMT in ayahuasca brews is thought to be responsible for the majority of the psychedelic effects of ayahuasca. However, many DMT-containing plants also contains its relative 5-MeO-DMT. Although the 5-MeO-DMT trip is less pleasant than DMT and more physically risky, it has been reported to be potentially very healing.

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Psychedelic Integration Guide for Bufo & 5-MeO-DMT

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